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1.
Conference Proceedings - IEEE SOUTHEASTCON ; 2023-April:610-617, 2023.
Article in English | Scopus | ID: covidwho-20242090

ABSTRACT

We demonstrate the feasibility of a generalized technique for semantic deduplication in temporal data domains using graph-based representations of data records. Structured data records with multiple timestamp attributes per record may be represented as a directed graph where the nodes represent the events and the edges represent event sequences. Edge weights are based on elapsed time between connecting nodes. In comparing two records, we may merge these directed graphs and determine a representative directed acyclic graph (DAG) inclusive of a subset of nodes and edges that maintain the transitive weights of the original graphs. This DAG may then be evaluated by weighting elapsed time equivalences between records at each node and measuring the fraction of nodes represented in the DAG versus the union of nodes between the records being compared. With this information, we establish a duplication score and use a specified threshold requirement to assert duplication. This method is referred to as Temporal Deduplication using Directed Acyclic Graphs (TD:DAG). TD:DAG significantly outperformed established ASNM and ASNM+LCS methods for datasets rep-resenting two disparate domains, COVID-19 government policy data and PlayStation Network (PSN) trophy data. TD:DAG produced highly effective and comparable F1 scores of 0.960 and 0.972 for the two datasets, respectively, versus 0.864/0.938 for ASNM+LCS and 0.817/0.708 for ASNM. © 2023 IEEE.

2.
2nd International Conference on Business Analytics for Technology and Security, ICBATS 2023 ; 2023.
Article in English | Scopus | ID: covidwho-20240134

ABSTRACT

This study aimed to evaluate the problems faced by dental patients during the COVID-19 pandemic. A total of 100 dental patients who had experienced post-complications due to the pandemic-induced lockdown were surveyed using a self-prepared questionnaire. The collected data were analyzed using statistical analysis with SPSS, and the study included 108 responders, of which 43% were male and 57% were female. The results were presented in pie charts and bar graphs. The findings revealed that the pandemic situation had a significant impact on dental patients, with disruptions to follow-ups and other related procedures. Overall, this study highlights the unexpected challenges faced by dental patients during the COVID-19 pandemic, emphasizing the need for additional measures to address the issues caused by this situation. © 2023 IEEE.

3.
Applied Sciences ; 13(11):6680, 2023.
Article in English | ProQuest Central | ID: covidwho-20235802

ABSTRACT

Existing deep learning-based methods for detecting fake news are uninterpretable, and they do not use external knowledge related to the news. As a result, the authors of the paper propose a graph matching-based approach combined with external knowledge to detect fake news. The approach focuses on extracting commonsense knowledge from news texts through knowledge extraction, extracting background knowledge related to news content from a commonsense knowledge graph through entity extraction and entity disambiguation, using external knowledge as evidence for news identification, and interpreting the final identification results through such evidence. To achieve the identification of fake news containing commonsense errors, the algorithm uses random walks graph matching and compares the commonsense knowledge embedded in the news content with the relevant external knowledge in the commonsense knowledge graph. The news is then discriminated as true or false based on the results of the comparative analysis. From the experimental results, the method can achieve 91.07%, 85.00%, and 89.47% accuracy, precision, and recall rates, respectively, in the task of identifying fake news containing commonsense errors.

4.
23rd Brazilian Symposium on GeoInformatics, GEOINFO 2022 ; : 360-365, 2022.
Article in English | Scopus | ID: covidwho-2322215

ABSTRACT

In 2019, a pandemic of the so-called new coronavirus (SARS-COV-II) began, which causes the disease COVID-19. In a short time after the first case appeared, hundreds of countries began to register new cases every day. Mapping and analyzing the flow of people, regardless of the mode of transport, can help us to understand and prevent several phenomena that can affect our society in different ways. Graphs are complex networks made up of points and edges. The (geo)graphs are graphs with known spatial location and, in the case of our study, the edges represent the flow between them. The (geo)graphs proved to be a promising tool for such analyses. In the study region, municipalities that first registered their COVID-19 cases are also municipalities that have the highest mobility indices analyzed: degree, betweenness and weight of edges. © 2022 National Institute for Space Research, INPE. All rights reserved.

5.
International Journal of Advanced Computer Science and Applications ; 14(4):456-463, 2023.
Article in English | Scopus | ID: covidwho-2321413

ABSTRACT

Online learning has gained a tremendous popularity in the last decade due to the facility to learn anytime, anything, anywhere from the ocean of web resources available. Especially the lockdown all over the world due to the Covid-19 pandemic has brought an enormous attention towards the online learning for value addition and skills development not only for the school/college students, but also to the working professionals. This massive growth in online learning has made the task of assessment very tedious and demands training, experience and resources. Automatic Question generation (AQG) techniques have been introduced to resolve this problem by deriving a question bank from the text documents. However, the performance of conventional AQG techniques is subject to the availability of large labelled training dataset. The requirement of deep linguistic knowledge for the generation of heuristic and hand-crafted rules to transform declarative sentence into interrogative sentence makes the problem further complicated. This paper presents a transfer learning-based text to text transformation model to generate the subjective and objective questions automatically from the text document. The proposed AQG model utilizes the Text-to-Text-Transfer-Transformer (T5) which reframes natural language processing tasks into a unified text-to-text-format and augments it with word sense disambiguation (WSD), ConceptNet and domain adaptation framework to improve the meaningfulness of the questions. Fast T5 library with beam-search decoding algorithm has been used here to reduce the model size and increase the speed of the model through quantization of the whole model by Open Neural Network Exchange (ONNX) framework. The keywords extraction in the proposed framework is performed using the Multipartite graphs to enhance the context awareness. The qualitative and quantitative performance of the proposed AQG model is evaluated through a comprehensive experimental analysis over the publicly available Squad dataset. © 2023, International Journal of Advanced Computer Science and Applications. All Rights Reserved.

6.
COVID-19 and a World of Ad Hoc Geographies: Volume 1 ; 1:907-921, 2022.
Article in English | Scopus | ID: covidwho-2327471

ABSTRACT

This chapter discusses the use and interpretation of graphs and maps concerning COVID-19 by ordinary people. Epidemiological data have experienced unprecedented communication in the official media as well as social networks. Media are using a vocabulary that includes such words and terms as "curve, " "flattening” and "inflection point” to describe the evolution of the pandemic. It can be assumed that there is an appropriation of this language about the impact that COVID-19 has had on people's daily lives. This impact concerns both the fear of infection and the expectation of the end of containment imposed by a majority of countries in the world. The maps presenting the epidemic on a global scale were used by people as a grid for reading, but above all for the extrapolation to the country of origin. Contrary to the wide availability of COVID-19 international maps, national and local maps in some countries such as Morocco have not had the same degree of usage. The use of non-graphical information at the local level has helped to balance this scale of knowledge about the spread and evolution of COVID-19. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

7.
Math Biosci Eng ; 20(6): 10659-10674, 2023 Apr 13.
Article in English | MEDLINE | ID: covidwho-2324457

ABSTRACT

To comprehend the etiology and pathogenesis of many illnesses, it is essential to identify disease-associated microRNAs (miRNAs). However, there are a number of challenges with current computational approaches, such as the lack of "negative samples", that is, confirmed irrelevant miRNA-disease pairs, and the poor performance in terms of predicting miRNAs related with "isolated diseases", i.e. illnesses with no known associated miRNAs, which presents the need for novel computational methods. In this study, for the purpose of predicting the connection between disease and miRNA, an inductive matrix completion model was designed, referred to as IMC-MDA. In the model of IMC-MDA, for each miRNA-disease pair, the predicted marks are calculated by combining the known miRNA-disease connection with the integrated disease similarities and miRNA similarities. Based on LOOCV, IMC-MDA had an AUC of 0.8034, which shows better performance than previous methods. Furthermore, experiments have validated the prediction of disease-related miRNAs for three major human diseases: colon cancer, kidney cancer, and lung cancer.


Subject(s)
Colonic Neoplasms , MicroRNAs , Humans , MicroRNAs/genetics , Genetic Predisposition to Disease , Algorithms , Computational Biology/methods , Colonic Neoplasms/genetics
8.
Stud Health Technol Inform ; 302: 747-748, 2023 May 18.
Article in English | MEDLINE | ID: covidwho-2323443

ABSTRACT

HealthECCO is the driving force behind the COVID-19 knowledge graph spanning multiple biomedical data domains. One way to access CovidGraph is SemSpect, an interface designed for data exploration in graphs. To showcase the possibilities that arise from integrating a variety of COVID-19 related data sources over the last three years, we present three use cases from the (bio-)medical domain. Availability: The project is open source and freely available from: https://healthecco.org/covidgraph/. The source code and documentation are available on GitHub: https://github.com/covidgraph.


Subject(s)
COVID-19 , Humans , Software , Documentation
9.
2022 International Conference on Smart Generation Computing, Communication and Networking, SMART GENCON 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2314141

ABSTRACT

SARS-CoV-2 is the name of the highly infectious Coronavirus that brought the disease to the world. Preventing Covid by keeping the partition among people since it is not possible to get relatable information of an individual about its contamination. The WHO considers 6-ft to be a safe separation for individuals who take all other necessary precautions (masks, sanitizing, etc.)[1]. The undertaking targets utilizing Artificial Insight to implement this social separation openly put by continually checking the separation between individuals shown in a video feed, also alarming the dependable individual to initiate the required moves. This video feed can be used without any problem gathered by the prior framework across the general population places like CCTV Cameras. This would enable us to continually observe the separation between any two people in a public place. The adaptability is exceptionally arranged highly, so that cameras are introduced at practically on every open spots[2]. © 2022 IEEE.

10.
Proc Natl Acad Sci U S A ; 120(20): e2221324120, 2023 05 16.
Article in English | MEDLINE | ID: covidwho-2320604

ABSTRACT

The frameshifting RNA element (FSE) in coronaviruses (CoVs) regulates the programmed -1 ribosomal frameshift (-1 PRF) mechanism common to many viruses. The FSE is of particular interest as a promising drug candidate. Its associated pseudoknot or stem loop structure is thought to play a large role in frameshifting and thus viral protein production. To investigate the FSE structural evolution, we use our graph theory-based methods for representing RNA secondary structures in the RNA-As-Graphs (RAG) framework to calculate conformational landscapes of viral FSEs with increasing sequence lengths for representative 10 Alpha and 13 Beta-CoVs. By following length-dependent conformational changes, we show that FSE sequences encode many possible competing stems which in turn favor certain FSE topologies, including a variety of pseudoknots, stem loops, and junctions. We explain alternative competing stems and topological FSE changes by recurring patterns of mutations. At the same time, FSE topology robustness can be understood by shifted stems within different sequence contexts and base pair coevolution. We further propose that the topology changes reflected by length-dependent conformations contribute to tuning the frameshifting efficiency. Our work provides tools to analyze virus sequence/structure correlations, explains how sequence and FSE structure have evolved for CoVs, and provides insights into potential mutations for therapeutic applications against a broad spectrum of CoV FSEs by targeting key sequence/structural transitions.


Subject(s)
Coronavirus Infections , Coronavirus , Humans , RNA, Viral/metabolism , Coronavirus/genetics , Coronavirus/metabolism , Base Sequence , Nucleic Acid Conformation , Frameshifting, Ribosomal/genetics , Coronavirus Infections/genetics
11.
Front Bioinform ; 2: 1054578, 2022.
Article in English | MEDLINE | ID: covidwho-2318929

ABSTRACT

Molecular "cartoons," such as pathway diagrams, provide a visual summary of biomedical research results and hypotheses. Their ubiquitous appearance within the literature indicates their universal application in mechanistic communication. A recent survey of pathway diagrams identified 64,643 pathway figures published between 1995 and 2019 with 1,112,551 mentions of 13,464 unique human genes participating in a wide variety of biological processes. Researchers generally create these diagrams using generic diagram editing software that does not itself embody any biomedical knowledge. Biomedical knowledge graphs (KGs) integrate and represent knowledge in a semantically consistent way, systematically capturing biomedical knowledge similar to that in molecular cartoons. KGs have the potential to provide context and precise details useful in drawing such figures. However, KGs cannot generally be translated directly into figures. They include substantial material irrelevant to the scientific point of a given figure and are often more detailed than is appropriate. How could KGs be used to facilitate the creation of molecular diagrams? Here we present a new approach towards cartoon image creation that utilizes the semantic structure of knowledge graphs to aid the production of molecular diagrams. We introduce a set of "semantic graphical actions" that select and transform the relational information between heterogeneous entities (e.g., genes, proteins, pathways, diseases) in a KG to produce diagram schematics that meet the scientific communication needs of the user. These semantic actions search, select, filter, transform, group, arrange, connect and extract relevant subgraphs from KGs based on meaning in biological terms, e.g., a protein upstream of a target in a pathway. To demonstrate the utility of this approach, we show how semantic graphical actions on KGs could have been used to produce three existing pathway diagrams in diverse biomedical domains: Down Syndrome, COVID-19, and neuroinflammation. Our focus is on recapitulating the semantic content of the figures, not the layout, glyphs, or other aesthetic aspects. Our results suggest that the use of KGs and semantic graphical actions to produce biomedical diagrams will reduce the effort required and improve the quality of this visual form of scientific communication.

12.
Robotics and Computer-Integrated Manufacturing ; 82, 2023.
Article in English | Web of Science | ID: covidwho-2309946

ABSTRACT

Digital twins and artificial intelligence have shown promise for improving the robustness, responsiveness, and productivity of industrial systems. However, traditional digital twin approaches are often only employed to augment single, static systems to optimise a particular process. This article presents a paradigm for combining digital twins and modular artificial intelligence algorithms to dynamically reconfigure manufacturing systems, including the layout, process parameters, and operation times of numerous assets to allow system decision -making in response to changing customer or market needs. A knowledge graph has been used as the enabler for this system-level decision-making. A simulation environment has been constructed to replicate the manufacturing process, with the example here of an industrial robotic manufacturing cell. The simulation environment is connected to a data pipeline and an application programming interface to assist the integration of multiple artificial intelligence methods. These methods are used to improve system decision-making and optimise the configuration of a manufacturing system to maximise user-selectable key performance indicators. In contrast to previous research, this framework incorporates artificial intelligence for decision -making and production line optimisation to provide a framework that can be used for a wide variety of manufacturing applications. The framework has been applied and validated in a real use case, with the automatic reconfiguration resulting in a process time improvement of approximately 10%.

13.
J Biomed Inform ; 142: 104382, 2023 06.
Article in English | MEDLINE | ID: covidwho-2307390

ABSTRACT

The article presents a workflow to create a question-answering system whose knowledge base combines knowledge graphs and scientific publications on coronaviruses. It is based on the experience gained in modeling evidence from research articles to provide answers to questions in natural language. The work contains best practices for acquiring scientific publications, tuning language models to identify and normalize relevant entities, creating representational models based on probabilistic topics, and formalizing an ontology that describes the associations between domain concepts supported by the scientific literature. All the resources generated in the domain of coronavirus are available openly as part of the Drugs4COVID initiative, and can be (re)-used independently or as a whole. They can be exploited by scientific communities conducting research related to SARS-CoV-2/COVID-19 and also by therapeutic communities, laboratories, etc., wishing to find and understand relationships between symptoms, drugs, active ingredients and their documentary evidence.


Subject(s)
COVID-19 , Humans , SARS-CoV-2 , Pattern Recognition, Automated , Publications
14.
Mathematics ; 11(6), 2023.
Article in English | Scopus | ID: covidwho-2290783

ABSTRACT

Using networks to analyze time series has become increasingly popular in recent years. Univariate and multivariate time series can be mapped to networks in order to examine both local and global behaviors. Visibility graph-based time series analysis is proposed herein;in this approach, individual time series are mapped to visibility graphs that characterize relevant states. Companies listed on the emerging market index Borsa Istanbul 100 (BIST 100) had their market visibility graphs collected. To further account for the local extreme values of the underlying time series, we constructed a novel kernel function of the visibility graphs. Via the provided novel measure, sector-level and sector-to-sector analyses are conducted using the kernel function associated with this metric. To examine sectoral trends, the COVID-19 crisis period was included in the study's data set. The findings indicate that an effective strategy for analyzing financial time series has been devised. © 2023 by the authors.

15.
ACM Transactions on Internet Technology ; 23(1), 2023.
Article in English | Scopus | ID: covidwho-2306388

ABSTRACT

The outbreak of Covid-19 has exposed the lack of medical resources, especially the lack of medical personnel. This results in time and space restrictions for medical services, and patients cannot obtain health information all the time and everywhere. Based on the medical knowledge graph, healthcare bots alleviate this burden effectively by providing patients with diagnosis guidance, pre-diagnosis, and post-diagnosis consultation services in the way of human-machine dialogue. However, the medical utterance is more complicated in language structure, and there are complex intention phenomena in semantics. It is a challenge to detect the single intent, multi-intent, and implicit intent of a patient's utterance. To this end, we create a high-quality annotated Chinese Medical query (utterance) dataset, CMedQ (about 16.8k queries in medical domain which includes single, multiple, and implicit intents). It is hard to detect intent on such a complex dataset through traditional text classification models. Thus, we propose a novel detect model Conco-ERNIE, using concept co-occurrence patterns to enhance the representation of pre-trained model ERNIE. These patterns are mined using Apriori algorithm and will be embedded via Node2Vec. Their features will be aggregated with semantic features into Conco-ERNIE by using an attention module, which can catch user explicit intents and also predict user implicit intents. Experiments on CMedQ demonstrates that Conco-ERNIE achieves outstanding performance over baseline. Based on Conco-ERNIE, we develop an intelligent healthcare bot, MedicalBot. To provide knowledge support for MedicalBot, we also build a Chinese medical graph, CMedKG (about 45k entities and 283k relationships). © 2023 Association for Computing Machinery.

16.
Advances in Epidemiological Modeling and Control of Viruses ; : 285-303, 2023.
Article in English | Scopus | ID: covidwho-2301286

ABSTRACT

The coronavirus disease (COVID-19) has affected many countries and taken the lives of several thousand of people since its outbreak in 2019. As in the case of other infectious diseases, several epidemiological models based on population-wide random mixing methods with the use of differential equations have been used in studying its transmission and spread. In such models, many details of the progression of the infection are often neglected, but in reality, every individual has a limited number of contacts they can pass infection to. The spread (pandemic) pattern of this virus can be analyzed from a graph theory perspective since it accounts for the contribution of each individual in the progression of a disease. The network is such that each vertex represents an individual at any particular stage of infection (asymptomatic, presymptomatic, or symptomatic), and edges indicate transmissions from person to person. In this chapter, we examine previous results on diseases that have been modeled using graph theoretical approaches. We later investigate the spread of COVID-19 among individuals within a population. In our study, we consider the neighborhood prevalence of each individual, i.e., proportion of each individual's contacts who are either exposed or infected, and introduce parameters α, β, and ϕ. In addition, we propose a threshold value R=n−22α(n−1) and describe the effects of R<1 and R>1 on the spread of the pandemic. These parameters can provide a generic understanding of the relationship between the network structure and the disease dynamics. © 2023 Elsevier Inc. All rights reserved.

17.
2nd International Semantic Intelligence Conference, ISIC 2022 ; 964:225-239, 2023.
Article in English | Scopus | ID: covidwho-2295846

ABSTRACT

During the COVID-19 pandemic, researchers started to develop technical approaches to solve the numerous challenges imposed by the new pandemic. One fundamental precondition for research is to make relevant data about the COVID-19 pandemic available in a machine-processable way. For this purpose, COVID-19 ontologies and knowledge graphs have been developed and proposed for many different subareas of COVID-19 applications and research. In this paper, we provide a short analysis of the impact of COVID-19 ontologies. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

18.
8th China Conference on China Health Information Processing, CHIP 2022 ; 1772 CCIS:156-169, 2023.
Article in English | Scopus | ID: covidwho-2277218

ABSTRACT

Question Answering based on Knowledge Graph (KG) has emerged as a popular research area in general domain. However, few works focus on the COVID-19 kg-based question answering, which is very valuable for biomedical domain. In addition, existing question answering methods rely on knowledge embedding models to represent knowledge (i.e., entities and questions), but the relations between entities are neglected. In this paper, we construct a COVID-19 knowledge graph and propose an end-to-end knowledge graph question answering approach that can utilize relation information to improve the performance. Experimental result shows that the effectiveness of our approach on the COVID-19 knowledge graph question answering. Our code and data are available at https://github.com/CHNcreater/COVID-19-KGQA. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

19.
16th ACM International Conference on Web Search and Data Mining, WSDM 2023 ; : 1273-1274, 2023.
Article in English | Scopus | ID: covidwho-2268780

ABSTRACT

A knowledge graph (KG) consists of numerous triples, in which each triple, i.e., (head entity, relation, tail entity), denotes a real-world assertion. Many large-scale KGs have been developed, e.g., general-purpose KGs Freebase and YAGO. Also, lots of domain-specific KGs are emerging, e.g., COVID-19 KGs, biomedical KGs, and agricultural KGs. By embedding KGs into low-dimensional vectors, i.e., representations of entities and relations, we could integrate KGs into machine learning models and enhance the performance of many prediction tasks, including search, recommendations, and question answering. During the construction, refinement, embedding, and application of KGs, a variety of KG learning algorithms have been developed to handle challenges in various real-world scenarios. Moreover, graph neural networks have also brought new opportunities to KG learning. This workshop aims to engage with active researchers from KG communities, recommendation communities, natural language processing communities, and other communities, and deliver state-of-the-art research insights into the core challenges in KG learning. © 2023 Owner/Author.

20.
13th IEEE International Conference on Knowledge Graph, ICKG 2022 ; : 79-86, 2022.
Article in English | Scopus | ID: covidwho-2261973

ABSTRACT

This paper presents a computational approach designed to construct and query a literature-based knowledge graph for predicting novel drug therapeutics. The main objective is to offer a platform that discovers drug combinations from FDA-approved drugs and accelerates their investigations by domain scientists. Specifically, the paper introduced the following algorithms: (1) an algorithm for constructing the knowledge graph from drug, gene, and disease mentions in the biomedical literature;(2) an algorithm for vetting the knowledge graph from drug combinations that may pose a risk of drug interaction;(3) and two querying algorithms for searching the knowledge graph by a single drug or a combination of drugs. The resulting knowledge graph had 844 drugs, 306 gene/protein features, and 19 disease mentions. The original number of drug combinations generated was 2,001. We queried the knowledge graph to eliminate noise generated from chemicals that are not drugs. This step resulted in 614 drug combinations. When vetting the knowledge graph to eliminate the potentially risky drug combinations, it resulted in predicting 200 combinations. Our domain expert manually eliminated extra 54 combinations which left only 146 combination candidates. Our three-layered knowledge graph, empowered by our algorithms, offered a tool that predicted drug combination therapeutics for scientists who can further investigate from the viewpoint of drug targets and side effects. © 2022 IEEE.

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